EXPERIMENTS AND OBSERVATIONS ON THE GASTRIC JUICE, AND THE PHYSIOLOGY OF DIGESTION.

Plattsburgh: Printed by F.P. Allen, 1833. 280pp. including in-text illustrations. Original half brown muslin and drab boards, printed paper label. Moderate edge wear, some soiling to boards, minor chipping to spine label and ends, small nick to front joint. Moderate occasional foxing; leaf C torn in outer margin (likely a paper flaw), not affecting text. A very good, unsophisticated copy. In a three-quarter morocco and cloth clamshell case, spine gilt. Item #WRCAM54979

The first edition of one of the landmarks of American medical literature, and a milestone which led prominently to the experiments of Pavlov almost a century later. This crudely printed and illustrated book, printed at the author's expense in an edition of 1000 copies (500 sets of sheets were later issued with a new titlepage), has been characterized as "the greatest contribution ever made to the knowledge of gastric digestion" (DAB). Through Beaumont's experiments and observations of gastric fistula sustained by Alexis St. Martin, he was able to establish many facts with regard to gastric physiology and chemistry, the majority of which are still regarded as sound. Dr. Thomas H. Johnson, in his introduction to the Grolier AMERICAN ONE HUNDRED, describes Beaumont's study as "a book that pushed back the frontier of the mind"; and Sir William Osler stated: "To the Medical Bibliographer there are few more treasured Americana...." This copy bears the ownership signature of J.M. Wieting on the front free endpaper, likely Dr. John M. Wieting (1817-88), a prominent physician and medical lecturer. GROLIER AMERICAN 100, 38. DIBNER, HERALDS OF SCIENCE 130. HORBLIT 10. STREETER SALE 4155. OSLER 1972. GARRISON-MORTON 989. HOWES B291, "b." GREENLY, MICHIGAN 67.

Price: $2,000.00

Pioneering American Medical Work